Drug Interactions-Important Points

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Drug Interactions-Important Points 1. Doctors must be careful in prescribing drugs with narrow therapeutic index, such as phenytoin, theophylline and digoxin, 2. Drugs which need proper dosage control, like hypoglycemics, antihypertensives and anticoagulants, need proper monitoring for drug interactions. 3. Old people and people with hepatic or renal impairment are potentially at risk, for adverse drug reactions. 4. Drug interaction causing agents include alcohol, tobacco, OTC drugs, NSAIDs and antacids. 5. Clinical importance of drug interactions depends on a variety of factors. 6. If there is less likelihood of an interaction with another member of a drug group, it is better to go for it. 7. When a drug interaction is suspected, careful monitoring should be done. 8. Dug information sources must be carefully studied and utilised for every given situation. Reference: 1. The Pharmaceutical Journal, (Vol 261), October 17, 1998, page 620. This blog does not contain plagiarised material.
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About the Author

Prof. J. Vijaya Ratna's picture

Dr. Vijaya Ratna Jayanthi serving Andhra University College of Pharmaceutical Sciences as Chairman, Pharmaceutical Technology Department.

Dr. J. Vijaya Ratna did her B.Pharm (1977), M.Pharm (1979), PGDAS (1981) and Ph.D (1998) at Andhra University Campus and won "M.L. Khorana Gold Medal" for standing University FIRST in graduation.

Comments

Bhavani Prasad.V's picture

Dear Madam, You said that NSAID's are drug interaction causing agents.Then since they cannot be avoided to administer, can you suggest how can we avoid such interactions?

Regards,

Bhavani Prasad.V

Prof. J. Vijaya Ratna's picture

NSIADs may also cause interactions. If it is a interaction with respect to ADME and it can be tolerated it is alright; or we can space the interacting drug and the PK interaction can be prevented it is alright; but if it is a interaction involving a drug like warfarin it may be serious. So, what I mean is patients using prescription drugs shouldn't use NSAIDs or Alcohol without telling the doctor. They must know that even such simple drugs may cause drug interactions. Many people do not even put alcohol and tobacco under the category of drugs. So i mentioned these three, NSAIDs and tobacco and alcohol in one sentence.
Uma Pratyusha's picture

Dear madam, You said that the clinical importance of drug interactions depend on a number of factors. Can you please tell me what those factors are?

Regards

Uma Prathyusha

Prof. J. Vijaya Ratna's picture

uma What category drug? How much pk changed? Is the interaction effect immediately felt? Embolism can be dangerous Lack of absorption of iron not dangerous Lack of quick control of pain not serious More anticoagulant in blood serious
Uma Pratyusha's picture

Dear madam, Thanks for that madam!

Regards

Uma Prathyusha

V.B.S.Aishwarya's picture

Dear madam, In answer to Prathyusha's reply,you said that lack of absorption of iron i s not dangerous, but then it causes anemia know madam?

Regards

V.B.S.Aishwarya

 

 

 

Prof. J. Vijaya Ratna's picture

Dear Aishwarya Lack of enough iron in our body may cause anemia which is an illness, thats all. It is not dangerous. But if someone using warfarin uses some other drug which causes more than the expected level of warfarin to be present in his/her blood; and if he accidentally sustains an injury; then he may have excessive anticoagulant activity in his blood which may cause bleeding which may result in something dangerous like death. So I am trying to draw a difference between a reaction which could cause a dangerous result to a reaction which could cause a minor illhealth. Vijaya Ratna
TK Indira's picture

Really focused blog.It may look very simple but these 8 points are the key factors. Thank you for sharing such important information mam.Every pharmacist should be aware of this and try to guide at-least up to their family which makes a small thread to guide millions.

T.K. Indira. http://www.pharmainfo.net/tkindira

-- "Our greatest glory is not in never falling, but in rising every time we fall..." Team 'Char'minar.

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