Hello my dear Pharmainfo friends, let us start our first basic step from calibration of basic lab requirements to sophisticated instruments.
Digital Analytical Balance:
It will not be shocking to say that digital balance is the first and foremost lab requirement. Accurate weighing results in desired finished product. It plays an important role at each and every stage. Therefore this blog emphasized on calibration of digital analytical balance.
The calibration is done using different standard weights. Example, the calibration of a digital analytical balance whose maximum capacity is 220 grams and minimum capacity is 10 mg includes the use of following standard weights and tolerance limits as per I.P.
20 mg:19.98 mg-20.02 mg (+-0.1)
50 mg: 49.95-50.05 (+-0.1)
2.00 gms: 1.9980-2.0020 (+-0.1)
10.00 gms: 9.99-10.01 (+-0.1)
Calibration should be done daily to avoid errors.
Operation of analytical balance should be done by choosing an optimum location with firm base, vibration free position with no extreme temperature fluctuation and excessive drafts (powerful air currents of fume hoods) for obtaining high accuracy.
Melting Point Apparatus:
It is used to identify a given sample or purity of a sample. It is the point at which a compound changes from solid to liquid. The point at which a compound starts melting and completes melting is called melting range.
No two solids or liquids have same melting or boiling point. We can determine melting point using capillary tube method.
Calibration of melting point is done using standard materials as listed
Table 1. Calibration of Melting Point Apparatus as per W.H.O.
First each and every parameter like media, thermometer, capillary tube and heater are checked. If the problem is not solved then it is sent for service engineering. Generally the problem may be chucked at the initial stages of calibration and verification of all parameters.
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W.H.O. - World Health Organization