Tablet Capping Causes and Remedies

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Tablet Capping Causes and Remedies

1.10.1.1 Capping (1,5)

Definition: 'Capping' is the term used, when the upper or lower segment of the tablet separates horizontally, either partially or completely from the main body of a tablet and comes off as a cap, during ejection from the tablet press, or during subsequent handling.

Reason: Capping is usually due to the air-entrapment in a compact during compression, and subsequent expansion of tablet on ejection of a tablet from a die.

Table.27. The Causes And Remedies Of Capping Related To 'Formulation' (Granulation)

Sr. No.

CAUSES

REMEDIES

1.

Large amount of fines in the granulation

Remove some or all fines through 100 to 200 mesh screen

2.

Too dry or very low moisture content (leading to loss of proper binding action).

Moisten the granules suitably. Add hygroscopic substance e.g.: sorbitol, methyl- cellulose or PEG-4000.

3.

Not thoroughly dried granules.

Dry the granules properly.

4.

Insufficient amount of binder or improper binder.

Increasing the mount of binder OR

Adding dry binder such as pre-gelatinized starch, gum acacia, powdered sorbitol, PVP, hydrophilic silica or powdered sugar.

5.

Insufficient or improper lubricant.

Increase the amount of lubricant or change the type of lubricant.

6.

Granular mass too cold to compress firm.

Compress at room temperature.

Table.28. The Causes And Remedies Of Capping Related To 'Machine' (Dies, Punches And Tablet Press)

Sr. No.

CAUSES

REMEDIES

1.

Poorly finished dies

Polish dies properly. Investigate other steels or other materials.

2.

Deep concave punches or beveled-edge faces of punches.

Use flat punches.

3.

Lower punch remains below the face of die during ejection.

Make proper setting of lower punch during ejection.

4.

Incorrect adjustment of sweep-off blade.

Adjust sweep-off blade correctly to facilitate proper ejection.

5.

High turret speed.

Reduce speed of turret (Increase dwell time).

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Tech Tip: Tablet Capping

About the Author

Dr.Mukesh Gohel's picture
Author: Dr.Mukesh Gohel

Dr. Mukesh Gohel is principal, professor at the LMCP, Ahmedabad served in academics for more than 40 years. He provides training in leading pharmaceutical industries in the areas of Design of Experiments and Quality by Design. His current areas of interest are direct compression and improvement of drug dissolution.

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