1.10.1.7
Pharmaceutical Tablet Binding
(1)
Definition: 'Binding' in the die, is the term used when the tablets adhere, seize or tear in the die.
A film is formed in the die and ejection of tablet is hindered. With excessive binding, the tablet sides are cracked and it may crumble apart.
Reason: Binding is usually due to excessive amount of moisture in granules, lack of lubrication and/or use of worn dies.
Table.39. The Causes And Remedies Of Binding Related To Formulation (Granulation)
|
Sr. No. |
CAUSES |
REMEDIES |
|
1. |
Too moist granules and extrudes around lower punch. |
Dry the granules properly. |
|
2. |
Insufficient or improper lubricant. |
Increase the amount of lubricant or use a more effective lubricant. |
|
3. |
Too coarse granules. |
Reduce granular size, add more fines, and increase the quantity of lubricant. |
|
4. |
Too hard granules for the lubricant to be effective. |
Modify granulation. Reduce granular size. |
|
5. |
Granular material very abrasive and cutting into dies. |
If coarse granules, reduce its size. Use wear-resistant dies. |
|
6. |
Granular material too warm, sticks to the die. |
Reduce temperature. Increase clearance if it is extruding. |
Table.40. The Causes And Remedies Of Binding Related To Machine (Dies, Punches And Tablet Press)
|
Sr. No. |
CAUSES |
REMEDIES |
|
1. |
Poorly finished dies. |
Polish the dies properly. |
|
2. |
Rough dies due to abrasion, corrosion. |
Investigate other steels or other materials or modify granulation. |
|
3. |
Undersized dies. Too little clearance. |
Rework to proper size. Increase clearance. |
|
4. |
Too much pressure in the tablet press. |
Reduce pressure. OR Modify granulation. |
About the Author
 Author: Dr.Mukesh Gohel
Dr. Mukesh Gohel is principal, professor at the LMCP, Ahmedabad served in academics for more than 40 years. He provides training in leading pharmaceutical industries in the areas of Design of Experiments and Quality by Design. His current areas of interest are direct compression and improvement of drug dissolution. |