1.10.1.7
Pharmaceutical Tablet Binding
(1)
Definition: 'Binding' in the die, is the term used when the tablets adhere, seize or tear in the die.
A film is formed in the die and ejection of tablet is hindered. With excessive binding, the tablet sides are cracked and it may crumble apart.
Reason: Binding is usually due to excessive amount of moisture in granules, lack of lubrication and/or use of worn dies.
Table.39. The Causes And Remedies Of Binding Related To Formulation (Granulation)
Sr. No. |
CAUSES |
REMEDIES |
1. |
Too moist granules and extrudes around lower punch. |
Dry the granules properly. |
2. |
Insufficient or improper lubricant. |
Increase the amount of lubricant or use a more effective lubricant. |
3. |
Too coarse granules. |
Reduce granular size, add more fines, and increase the quantity of lubricant. |
4. |
Too hard granules for the lubricant to be effective. |
Modify granulation. Reduce granular size. |
5. |
Granular material very abrasive and cutting into dies. |
If coarse granules, reduce its size. Use wear-resistant dies. |
6. |
Granular material too warm, sticks to the die. |
Reduce temperature. Increase clearance if it is extruding. |
Table.40. The Causes And Remedies Of Binding Related To Machine (Dies, Punches And Tablet Press)
Sr. No. |
CAUSES |
REMEDIES |
1. |
Poorly finished dies. |
Polish the dies properly. |
2. |
Rough dies due to abrasion, corrosion. |
Investigate other steels or other materials or modify granulation. |
3. |
Undersized dies. Too little clearance. |
Rework to proper size. Increase clearance. |
4. |
Too much pressure in the tablet press. |
Reduce pressure. OR Modify granulation. |