HYDROGEL DRUG DELIVERY HOLDS PROMISE IN FUTURE OF MEDICINE

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Hi bloggers here iam with my first topic of the month of july "HYDROGEL DRUG DELIVERY HOLDS PROMISE IN FUTURE OF MEDICINE" INTRODUCTION: The hydrogels were discovered by Wichterle and Lim in 1960. Hydrogels are three dimensional hydrophilic polymer networks whch are highly permeable to several drug compounds and also can tolerate acidic conditions inside the body and can swell to maximum extent when tailored accordingly which can there by release the entrapped drug through their web like surfaces. Once formulated as a hydrogel, the rate of drug release depends on the crosslinking ratio of the polymer network.[1] TYPES OF HYDROGELS: Hydrogels can be prepared by using either natural or synthetic polymers. Based on the type of polymer used the hydrogel may be biodegradable hydrogel or biomimetic hydrogel.[1] Hydrogels as designed can be made sensitive to the environment. Based on their sensitivity they may be pH sensitive, temperature sensitive, enzyme sensitive and electrical sensitive hydrogels.[2] PREPARATION OF HYDROGELS: The basic approach for the synthesis of hydrogel involves copolymerization/crosslinking of co-monomers using multifunctional co-monomer, which acts as crosslinking agent which is achieved by one of the following suitable techniques.[2] 1. Solution polymerization/crosslinking 2. Suspension polymerization 3. Polymerization by irradiation 4. Chemically crosslinked hydrogel 5. Physically crosslinked hydrogels APPLICATIONS:[1] * Hydrogels can be used for the synthesis of sustained or targeted or stealth biomolecule delivery type dosage forms. * Hydrogels can exihibit bioadhesive property as well to facilitate the drug targeting mainly for non-invasive drug administration through mucus membranes. * Contact lenses and surgical dressings synthesized as hydrogels are being used successfully. [3] *They can also be used: [3] 1. as a super absorbent material in diaper, 2. as insulator construction materials, 3. as water retention material in agricultural applications, 4. in cosmetic and pharmaceutics industry, 5. in artificial organs and tissue engineering, 6. in wound dressings and in fire protection. CONCLUSION: According to the present day scenario with the increased efforts devoted to the controlled release formulations it is evident that the applications of hydrogels will definitely grow in future. REFERENCES: [1]Pharma Buzz,An assemblage of pharmaceutical resources, A National Pharma Monthly Magazine, December 2009, Volume 4, Issue 12. Page no:20-24 [2]HTTP://WWW.IJPSONLINE.COM/ARTICLE.ASP?ISSN=0250-474X;YEAR=2006;VOLUME=68;ISSUE=2;SPAGE=133;EPAGE=140;AULAST=SATISH Checked on 15 july 11:10PM [3]HTTP://WWW.GZESPACE.COM/NEW/ENG/HYDROGELS.HTML Checked on 15 july 11:15PM "THIS BLOG DONOT CONTAIN ANY PLAGIARISED MATERIAL"

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Siva Mavuduru's picture

a complete blog sir
Siriki Praveen Kumar's picture

thanks siva.....

Regards,

S. Praveen Kumar.

sirikipraveen11@gmail.com

Pharma warriors

Satyajeeth Pandey's picture

Good work praveen

Satyajit Panda Asst. professor Maharajah's College Of Pharmacy

Siriki Praveen Kumar's picture

thankyou sir,,,,,..........

Regards,

S. Praveen Kumar.

sirikipraveen11@gmail.com

Pharma warriors

SS Md Shafi's picture

hi dear nice blog.... is there any disadvantages with these?

shafi ..

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