Drug Interactions of Antibiotics

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The following list of antibiotics are reported to show
interactions listed in CIIMS book.


DRUG

Interacts
with:

Amikacin

Amphotericn
B, Diuretics

Amoxicillin

Disulfurum,
Probencid, Tetracycline, Chloramphenicol, Anticoagulants

Azithromycin

Antacids,
Ergot alkaloids, Digoxin, Ciclosporin

Aztreonam

Oral anti-coagulants

Bacampiciiln

Probencid,
Chloramphenicol, Teracycline, Anti-coagulants

Cefaclor

Probencid,
Aminoglycoside, Furosemide, Anti-coagulants

Cefadroxil

Anti-cagulants,
Probencid

Cefalexin

Probencid,
Aminoglycosides, Furosemide

Cefaloridine

Probencid,
Aminoglycosides, Furosemide

Cefazolin

Probencid,
Furosemide, Aminoglycosides

Cefdinir

Probencid,
Iron, Antacids

Cefepime

Probencid,
Aminoglycosides

Cefixime

Probencid,
Anticoagulants

Cefeperazone

Alcohol,
Anti-coagulants, Aminoglycosides, Furosemide

Cefotaxime

Probencid, Aminoglycosides, Furosemide

Cefprirome

Probencid

Cefpodoxime

Probencid, Antacids, H2 blockers, Furosemide

Cefprozil

Probencid, Oral contraceptives (estrogen containing)

Ceftazidime

Probencid, Aminoglycosides, Furosemide

Ceftizoxime

Probencid, Aminoglycosides, Furosemide

Ceftriaxone

Alcohol, Aminoglycosides, Furosemide

Cefuroxime

Probencid, Aminoglycosides, Furosemide

Chloramphenicol

Iron,
Vitamin B12, Phenobarbitone, Rifampicin, Oral contraceptives, Oral
anticoagulants, oral hypoglycemic agents, phenytoin

Ciprofloxacin

Antacids (Mg and Al),
Multivitamins (Ca, Fe, Zn and Mg), Methotrexate, Caffeine, Probencid, oral
anticoagulants, glibencamide, Corticosteroids, ciclosporin, quinolines,
NSAIDs, theophylline, tizanidine

Clarithromycin

Oral
anticoagulants, digoxin, terfenadine, astemizole

Clindamycin

Parasympathetics,
Neuromuscular blockers

Cloxacillin

Probencid,
Disulfuram, Chloramphenicol, Tetracycline, Oral anti-coagulants

Co-trimoxazole (Sulphametoxazole+ Trimethoprim)

Ciclosporin, Methotrexate, Phenytoin, Warfarin , Oral hypoglycemics,
Pyrimethamine

Demeclcycline

Antacids,
Calcium, Iron, Rifampicin, Phenytoin, Carbamazepine,

Erythromycin

Lincomycins,
Clindamycins, Alcohol, Neuromuscular blockers, Oral; anticoagulants,
ciclosporin, theophylline, terfenadine, astemizole, cisapride

Gatifloxacin

Antacids,
Ferrous salts, Zn salts, Digoxin, Probencid, Cimetidine, Loop diuretics, erythromycin, phenothiazines, TCAs,
corticosteroids, oral antidiabetic drugs, oral anticoagulants, anti- arrhythmic

Gemifloxacin

Al, Mg and Fe salts,
Cisapride, erythromycin, antipyschotics, TCAs, Warfarin

Gentamicin

Ampicillin,
Benzyl penicillin, Anesthetics, opoids, ethacrynic acid, furosemide,
cephalosporin, ciclosporin, cisplatin, vancomycin, indomethacin

Kanamycin

Ampicillin, Benzyl
pencillin, Ethacrynic acid, Furosemide, Cephalosporins, Ciclosporins,
Vancomycin, Hydrocortisone, Indomethacin

Levofloxacin

Ciclosporins,
Iron salts, Theophylline, Corticosteroids, Antacids, Procainamide,
Antidiabetic agents, Anti-arrythmics, NSAIDs, Warfarin

Lincomycin

Neuromuscular
blocking agents, erythromycin

Lomefloxacin

Antacids,
Mutivitamins, Cimetidine, Ciclosporin, probencid, anti-arrythmias

Meropenam

Probencid, Valproic
acid

Minocycline

Antacids,
oral contraceptives, lithium, theophylline, oral anticoagulants,
isotretinion, ethinyl estradiol

Moxifloxacin

Antacids, Ferrous
salts, NSAIDs, Corticosteroids, Anti-coagulants, Anti arrhythmics, mycophenolate,
terfenadine, astemizole

Nalidixic acid

Probencid,
Chloramphenicol, Nitrofurantoin, Tetracycline, Melphalen, Ciclosporin, oral
anticoagulants

Nitrofurantoin

Probencid,
Sulfinpyrazone, quinolone, ACrbonic anhydrase inhibitors, urinary
alkalinisers

Norfloxacin

Antacids,
Probencid, clozapine, NSAIDs, Theophylline, Ciclosporin, Warfarin,
anti-arrythmics, erythromycin, antipsychotics, TCAs

Ofloxacin

Probencid, Antacids,
Cimetidine, Corticosteroids, Oral anticoagulants, Ciclosporin, Theophylline,
NSAIDs, Erythromycin, Phenothiazines, Anti- arrhythmics

Oxytetracycline

Antacids,
Lithium, Digoxin, Theophylline, Ergot alkaloids, Diuretics

Polymixin B

Neuromuscular
blockers, Vancomycin, Cefalotin, Aminoglycosides

Roxithromycin

Ciclosporin,
Digoxin, Simvastin

Sparfloxacin

Theophylline,
Warfarin, Glibencamide, Methotrexate, Probencid, Phenytoin, Corticosteroids,
NDAIDs, Anti-arrythmics, Phenothiazines, TCAs

Spiramycin

Carbidopa,
Levidopa, Astemiazole, Cisapride, Terfenadine, Fluphenazine

Sulfadiazine

Sulphonyl ureas,
Local anasthetics, Oral anticoagulants, Methotrexate, Ciclosporin, Ascorbic
acid

Sulfamoxole

Phenytoin,
Methotrexate, warfarin, clozapine, pyrimethamine

Tetracycline

Fe salts, Antacids,
Lithium, Digoxin, Theophylline, Warfarin, Diuretics

Tobramycin

Ethacrynic
acid, Furosemide, Aminoglycosides, Cisplatin, VAncomycin, Ciclosporin,
Amphotericin B, Miconazole, Neuromuscular- blocking agents

Vancomycin

Aminoglycosides,
Cisplatin, NSAIDs, Amphotericin B, Polymycin B, Neuromuscular blockers, Loop
diuretics, Ethacrynic acid, methotrexate, dopamine, dobutamine, zidovudine.


Reference: CIMS: July- Sept. 2009; Update: 3, Pg nos: 266- 348

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Comments

TK Indira's picture

Very important concept. Thanks for sharing.

T.K. Indira. http://www.pharmainfo.net/tkindira

-- "Our greatest glory is not in never falling, but in rising every time we fall..." Team 'Char'minar.

Bhavani Prasad.V's picture

Hi Santosh, It would have been nice if you have included a column on the effects the drugs show due to interaction.

Regards,

Bhavani Prasad.V

Uma Pratyusha's picture

Hi Santosh, Can you please suggest what kind of effects these antibiotics show due to those interactions?

Regards

Uma Prathyusha

Amol Malpani's picture

Dear Santosh, Without mentioning the effect inside the body of these interactions, this page doesn't look complete. You done lot of hard work for it, which is reflected but it is look like water and sugar is mixed with each other then........whether it is converted to tea, or juice or simply mixture of sweet water and which taste one will get no one knows. Hope you will take it as positively and consider this in your next pages. Regards,
Santosh kumar. JH's picture

Dear Sir, With the intension of giving an comprehensive report, I made it simple with out going in-dept of pharmaco-dynamic and pharmacokinetic effects of these interactions. I will try to modify the page it as early as possible... Thank You!!
V.B.S.Aishwarya's picture

Hi Santosh, While seeing the table, I have observed that most of the antibiotics react with anticoagulants. Why is it so?

Regards

V.B.S.Aishwarya

 

 

 

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