Smart Polymer Based Delivery Systems for Peptides and Proteins

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Biodegradable polymeric systems represent delivering many bioactive agents, includingpeptide and protein drugs. The importance has been advanced in the understanding of peptide and protein pharmacology as well as the ability to bulk production of these compounds. Upon admistration some plymer undergoes sol-gel transition.. In situ gel formation happens in response to one or a combination of two or more stimuli they include UV-irradiation, pH change, temperature change, and solvent exchange. Smart polymeric systems have several advantages over conventional methods, such as ease of manufacturing, ease of administration, biodegradability, and the ability to alter release profiles of the incorporated agents. In this review we introduce the different strategies that have been developed and patented for the use of smart polymers in delivering peptide and protein drugs. The advantage, disadvantages, possibilities, and limitations of each of the smart polymer systems have been discussed in detail. Keywords: Drug delivery, controlled release, smart polymer, in situ, injectable, peptide, protein.

 

Profile page link of the author: http://www.pharmainfo.net/md-vaseevur-rahaman

Profile page link of the guide: http://www.pharmainfo.net/ramamohan

 

Comments

ketanchaudhari's picture

Can u please elaborate on the use of photosensitive polymers in the drug delivery as Inside the body polymers can not get the photosensitivity to change the characteristics

KETAN CHAUDHARI

Md. Vaseevur Rahaman's picture

Hi friend please re frame your question so that I can reply you well right.
Arun Kumar Palle's picture

Very nice presentation keep it up. You have mentioned about a sustained release, and less side effects. >But how this system is useful when the person acquires drug tolerance. >There many side effects with sustained release dosage from, then how can this system over come these disadvantages when released in prolonged manner. >Is this system suitable for all drugs
Md. Vaseevur Rahaman's picture

Your Question : Q 1. How this system is useful when the person acquires drug tolerance ? Ans : Good question friend this systems are at very initial stages of development and if you take any drug in allopathy most of the drugs are having tolerance & sideeffects so as the science wings are much more expanded with respect to new inventions & modifications in the older drugs, there would be few changes in next generation drugs if such complications come accross.
Abhishek Rathi's picture

Dear Author, Great efforts, I have few queries regarding oral route, 1.As it is mentioned that it is convenient and popular,but u have told,that it is degraded by GIT Enzymes and has poor permeability....then how it is convenient? 2.What are PPDDS?

Abhishek Rathi

Md. Vaseevur Rahaman's picture

Your Question : Q 1. As it is mentioned that it is convenient and popular,but u have told,that it is degraded by GIT Enzymes and has poor permeability....then how it is convenient? Ans : Before going to develop any dosage form we do all efforts for convenient dosage form right, at that sense it was found that Oral route is more convenient and problems associated with that are observed later. But yet it is popular and convenient compared to other routes like transdermal, rectal, vaginal, and injectables like intramuscular, intravenous, subcutaneous but this dosages forms are poorly accepted by the patients. Q 2. What are PPDDS? Ans : It is the title of my PPT, PROTEIN PEPTIED DRUG DELIVERY SYSTEM. Thanks for the comment.
Abhishek Rathi's picture

Dear Vasuveer, I would also like to know that in case of temperature sensitive polymers,is there any specific temperature or a range at which the activity starts?

Abhishek Rathi

Anil kumar appapurapu's picture

Abstract: 1. "Smart polymeric systems have several advantages over conventional methods, such as ease of manufacturing, ease of administration, biodegradability, and the ability to alter release profiles of the incorporated agents" Q1) Drugs are of low mlo.wt and polymers are of high mol.wt as per theories of blood transport mechanisms only small mol.wt drug substances can be transported by cell membrane. Q2) Give the comment on transportation of polymer based drug delivery systems in compare conventional dosage forms 2. "Upon administration some polymer undergoes sol-gel transition.." Q3) what is the importance of sol-gel transition and is it applicable to all type of drugs pls write a comment onthis

anilkumar

Md. Vaseevur Rahaman's picture

Good question Mr. Anil Your Question : Q 1. Drugs are of low mlo.wt and polymers are of high mol.wt as per theories of blood transport mechanisms only small mol.wt drug substances can be transported by cell membrane. Ans : Yes, as per theories of blood transport mechanisms only small mol.wt drugs substances can be transported by cell membrane, but here we are making use of smart polymers to stabilize proteins that are to be administered and to facilitate transport we are designing these SMART POLYMERS with use of NANO TECHNOLOGY as we all of us know that nano particle can be easily administered and get easily transported and have no such complications. But as we are using polymers problems associated with membrane permeability is concerned to a little extent and still researches are going on for developing this systems. ok thanks for comment.
Md. Vaseevur Rahaman's picture

To add few words about the SMART POLYMERS which are prepared rather than nano technology like macromolecules they form implants at the site of action and mostly used for drugs that are to be released for longer periods so that number of injections can be reduced.
Sandeep Reddy's picture

1)weather this system is useful for all drugs 2)if this shows any effect on protein synthesis then what is your comment 3)give examples on disease treatment
Md. Vaseevur Rahaman's picture

smart question friend, Your question Q 1. Weather this system is useful for all drugs? Ans : No, this system is not useful for all types of drugs but most conventionally it is used where controlled release of drug is essential. Q 2. Do this system shows any effect on protein synthesis right. Ans : Yes friend as this system has developed based on recombinant DNA technology it will show changes in the protien synthesis to those proteins which are developed form recombinant DNA but do not show any changes in normal protein synthesis. Q 3. Diseases that are cured with this technology ? Ans : These dosage form has much use and is used to treat dangerous diseases like Cancer Therapy and where controlled drug release is essential.
Sandeep Reddy's picture

hi fnd nice answering but i have still questions to ask you .......... 1)can write any ADRs by this technology
G.Sailesh's picture

Do you mean to say that smart polymers are those polymers which respond to external changes such as pH, temperature or phase transition? If so Why? and If not Why? What is the particular advantage that is likely to be obtained by applying these polymers in delivery of proteins and peptides? Can we use such type of polymers in delivery of normal drug molecules that is other than proteins and peptides?
Md. Vaseevur Rahaman's picture

Hai sailesh, firstly I thank you for seeing my presentation and posing question, Your Question : 1. Do you mean that smart polymers are those polymers which respond to external changes such as pH, temperature or phase transition ? Ans : Dear sailesh,It is not like that smart polymers have some property to change their characterestics with response to the external stimuli or environment and it will differ from one polymer to other like temperature, phase sensitive, pH sensitive, photo sensitive polymer right, and we are making use of this property and applying them at our use.
G.Sailesh's picture

So you mean that they inherently posses a property of responding to pH, temperature and they exhibit it after reaching the biological system? Am I right?
Md. Vaseevur Rahaman's picture

I think you are having one more question. Q 2. Your 2nd question is that could we use smart polymers in delivery of normal drug molecules that is other than proteins and peptides ? Good this is an informative question and you want to make use of smart polymers in any other conventional dosages form rather than protein and peptide drug delivery system, but sailesh polymers are not needed to design a drug other than proteins and sustained release drugs. And in my PPT inorder to deliver proteins inside the body as the proteins are unstable both physically and chemically to over come this problem we are using smart polymers to stabilize the proteins so that we can attain good theraputic efficacy ok !
G.Sailesh's picture

So, I can use these smart polymers in design of a sustained or controlled release of normal drug molecules. Can I? How these smart polymers are helpful in stabilising the proteins or peptides? Chemically how these smart polymers differ from normal polymers (i.e., whether they consist of monomers of only amino acids or any kind of monomer it may possess)
Anil kumar appapurapu's picture

good presentation, here the ppt based questions pls reply for all 1. slide no. 4 can you explain the point no.5 "possibility to specific mode of action" elaborately? 2. slide no. 8 proteins and peptides are large molecules, can we go through parenteral administration? if so wt precautions to be taken? 3. slide no. 10 pls explain Structure Vs Degradation of proteins in physical stability. 4. slide no. 13 in continuous to this slide " what are the various driving forces that causes transitional changes? 5. slide no. 20 give the examples of water soluble macromers? thank you

anilkumar

Md. Vaseevur Rahaman's picture

PPDD system show specific mode of action, it means these systems can be for drugs to deliver specifically at closer touch to meet its pharmacological action like Transdermal patches, implants etc.
SS Md Shafi's picture

hi... what are the general tests for limits for these systems...?? Are they similar to the tests for other normal drugs...??

shafi ..

SS Md Shafi's picture

hi... could you plz..provide example for any marketed formulation of these...???

shafi ..

Arun Kumar Palle's picture

>can you explain me about the Structure Vs Degradation of proteins?
Arun Kumar Palle's picture

Can you explain me about the usage in gene therapy
Md. Vaseevur Rahaman's picture

Of course this system is based on R-DNA it is developed based on Gene therapy.
Harsh bansal's picture

hello vaseevur can u please explain that by which mechanism Degradation of proteins will occurs ? thank you

harsh bansal

Sandeep Reddy's picture

hi rhaman can you write any adverse drug reactions by this method
Md. Vaseevur Rahaman's picture

Q. Do we have any adverse effects with this method drug delivery system ? right, Ans : Freind most of the proteins that we have administered are mainly for implants are for site specific, IV but after showing the theraputic action most of the proteins get degraded so we named them as biodegradle ok but problems related to preparation are quitly faced like stability, large size etc. but these problems have over come so far..
Harsh bansal's picture

hello vaseevur its last day today... its very nice to meet u through this competition your presentation is nice all the best for your future thank you

harsh bansal

Pooja Chowdary's picture

ALL THE BEST...

pooja

Sirisha Pingali's picture

GOOD LUCK FOR YOUR FUTURE

Sirisha Pingali

http://www.pharmainfo.net/sirisha

Viswanadha Institute of Pharmaceutical Sciences.

www.vnips.edu.in

Abhishek Rathi's picture

Dear Author, All the best. Its been a very nice experience. It was a really awesome and knowledgeable. Thanks & Regards

Abhishek Rathi

Arun Kumar Palle's picture

Dear Author Iam very much glad to meet you through this competition. And wish you all the best with regards Arun kumar palle & V.R.M.Gupta
SS Md Shafi's picture

HI.. ALL THE BEST 2 ALL...

shafi ..

Md. Vaseevur Rahaman's picture

All the best to you all Guys!
J Singh's picture

The abstract and all contentform your presentation is very same as that of paper on link http://www.bentham.org/ddf/samples/ddf%201-1/J.Singh.pdf. Please mention proper citation.ALWAYS !!!

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