Biodegradable polymeric systems represent delivering many bioactive agents, includingpeptide and protein drugs. The importance has been advanced in the understanding of peptide and protein pharmacology as well as the ability to bulk production of these compounds. Upon admistration some plymer undergoes sol-gel transition.. In situ gel formation happens in response to one or a combination of two or more stimuli they include UV-irradiation, pH change, temperature change, and solvent exchange. Smart polymeric systems have several advantages over conventional methods, such as ease of manufacturing, ease of administration, biodegradability, and the ability to alter release profiles of the incorporated agents. In this review we introduce the different strategies that have been developed and patented for the use of smart polymers in delivering peptide and protein drugs. The advantage, disadvantages, possibilities, and limitations of each of the smart polymer systems have been discussed in detail. Keywords: Drug delivery, controlled release, smart polymer, in situ, injectable, peptide, protein.
Profile page link of the author: http://www.pharmainfo.net/md-vaseevur-rahaman
Profile page link of the guide: http://www.pharmainfo.net/ramamohan