Some unusual dosage forms

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> Convenience of administration & patient compliance are gaining significant importance in the design of dosage forms.
> In recent times, more stress is set on the development of an organoleptically elegant and patient-friendly drug delivery system for pediatric and geriatric patients.
> Novelty in terms of dosage form designing is needed for several reasons like taste masking, better therapeutic efficacy etc but the primary objective is better patient compliance.
> Following un-usual dosage forms are discussed in this presentation;
>>> Lollipops
>>> Oral syringes
>>> Medicated cigarettes
>>> Oral bandages
> Unusual or different from routine, have ability to attract attention of patient especially in pediatric and geriatric patients.
> Moreover, it helps in delivering drug at desired site, so better therapeutic efficiency can be achieved within optimum quantity.
> Awareness about such dosage form is less compared to other dosage form, so these should be highlighted.

Key words : Unusual dosage forms, medicated cigarettes, lollipops, oral bandages

Profile page link of the author : http://www.pharmainfo.net/anuya-shrivastava
Profile page link of the guide : http://www.pharmainfo.net/majumdarshiv

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Comments

Abhishek Rathi's picture

Dear Mam, Really something novel & unusual to know after seeing your presentation. As you said, it is glimpse of other unusual forms, can you quote other example also. Regards

Abhishek Rathi

Anuya Shrivastava's picture

Dear Abhishek, Thanks for the appreciation. About other unusual dosage forms, I am enlisting few more along with its reference 1) Medicated Lipsticks (Shaikh S, Bhise K. Formulation and evaluation of medicated lipstick of allantoin. Asian J Pharm 2008;2:91-5, European Patent EP0948332) 2) Nail lacquer (http://www.patient.co.uk/medicine/Amorolfine-nail-lacquer.htm) 3) Chewing gums (http://www.usp.org/pdf/EN/USPNF/Vol34No3Stimuli2.pdf) I hope this links will highlight few aspects of other unusual dosage form. Regards
Harsh bansal's picture

hello anuya, first of all i want to say that your ppts are good and fast animations are very attractive, now i have i little quarry from your slides, in slide no 7 u said precaution not be chewed and swallowed at once do you think it easy to understand for children s ? and what is the disadvantage in that case if any one swallowed it?? and 2nd is oral syringe do you not think its a too invasive method ??

harsh bansal

Anuya Shrivastava's picture

Dear Harsh, Thanks for the appreciation, About your queries 1) Precaution to be taken, if in case it is swallowed then first of all the drug selected for this dosage form will have safety margin (non-potent) so will not have any hazardous effect. & the excipients will also have solubility intoxicant nature & solubility with body fluid. so no question of harmful effect. Children are used to such stuffs so, easy to understand by such patient community. 2)Oral syringe is free from needle so it won't puncture or invade any tissue. Hence it won't be a invasive method. I hope my answer clarifies the queries. Regards
Sudha Thamarapalli's picture

Hai, If the drugs used are not potent then the dose will be more. Can you tell me the maxinmum dose that can be incorporated in these types? Regards, SUDHA.T

Regards,

Sudha.T

Harsh bansal's picture

ya is it... i am satisfied fro your ans. actually i am very afraid of syringe like snakes so i think is better to ask about it for future right? any way and if you have any query about my ppts you can ask me harshbansal23@rocketmail.com thank you

harsh bansal

Harsh bansal's picture

anuya first your name is too good and unique, medicated cigarettes is it tech. use for pulmonary drug delivery? and in slide no 13 you use word evaporation of solvent evaporation is possible in side of mouth??

harsh bansal

Anuya Shrivastava's picture

Dear Harsh, Thanks for the comments. About evaporation of solvents in mouth, the vapors will be inhaled & it can be expelled from nasal route. So evaporation of gaseous will be considered as evaporation of solvent. Generally this technology is mentioned in Ayurveda described in disorders of Pulmonary diseases. I hope my answer clarified your queries. Regards
Arun Kumar Palle's picture

Can you please explain me about other type like chewing gums?
Anuya Shrivastava's picture

Dear Arun, Following are the things that explains about chewing gum. Medicated Chewing Gum (MCG) is a novel drug delivery system containing masticatory gum base with pharmacologically active ingredient and intended to use for local treatment of mouth diseases or systemic absorption through oral mucosa. MCG is considered as vehicle or a drug delivery system to administer active principles that can improve health and nutrition. The present article reviews MCG Drug Delivery System concepts including its merits and demerits. COMPONENTS OF MCG: Chewing gum is a mixture of natural or synthetic gums and resins, sweetened with sugar, corn syrup, artificial sweetners and may also contain colouring agents and flavour. The basic raw material for all CG is natural gum Chicle, obtained from the sapodilla tree. Chicle is very expensive and difficult to procure therefore other natural gum or synthetic materials like polyvinylacetate and similar polymers can be used as gum base. Typically Chewing Gum comprises two parts 1.Water insoluble chewable gum base portion 2.Water-soluble bulk portion Reference: http://www.pharmainfo.net/reviews/medicated-chewing-gum-new-reformulatio... Regards
Arun Kumar Palle's picture

Thanks for answering. But you missed how drug is released from it?
Arun Kumar Palle's picture

can you please explain about any marketing products of you specified type apart from you said?
Anuya Shrivastava's picture

Dear Arun, Following are examples about marketed / patented formulation of the dosage forms I mentioned in my presentation 1) Medicated Cigarettes : Long Happiness (http://tobaccodocuments.org/pm/2023132382-2389.html) 2) Oral Syringes: Monoject Oral Syringe (http://www.nextag.com/oral-syringe/stores-html) 3) Oral Bandages : GUM Rincinol P.R.N. Soothing Oral Bandage, 4-Ounce Bottle (http://www.amazon.com/dp/B001ET7G9Y/ref=asc_df_B001ET7G9Y1297728?tag=the...) 4) Lollipops: Tetracycline lollipops by Bedford Pharmacy. (http://www.bedfordpharmacy.com/_pdf/_patient_info/Tetracaine-lollipop-pa...) I hope theses description clarifies your queries. Regards
Arun Kumar Palle's picture

Thanks for answering
Arun Kumar Palle's picture

Can you please specify me drugs which can be formulated in this manner? If antibiotics can be fromulated then what is the effect on oral microbes when oral route is selected?
Anuya Shrivastava's picture

Dear Arun, Drug which have broad safety margin are generally selected for such dosage form & its therapeutic consideration is also kept in consideration. About antibiotics, those which are stable eg. tetracycline in lollipos (reference listed in earlier answer)can be used. Regards
Pooja Chowdary's picture

I am amazed to know that even cigarrete can be a form of drug delivery system.......something which have been defamed for causing disease like cancer...very truely said everything has two facet and it depends on an individual which facet to accept!!!

pooja

Anuya Shrivastava's picture

Dear Pooja, Good to see your reaction, thanks for that. About cancer, cigarette is used as medium, main cause is tobacco. So technology is used without its harmful causative thing. Medicated cigarette is older & listed in Ayurveda also. We just explored that heritage. Keep sending your comments. Regards
Pooja Chowdary's picture

I heard in market some cigarettes are present with mint n clove like flavors (I m not sure about the availability in market but I heard such products are available in market) Are these preparations having any medicinal value?

pooja

Anuya Shrivastava's picture

Dear Pooja, Yeah few brands are available in market which have clove in their preparation, but it consist tobacco also. so it is used as flavouring purpose only, no medicinal value. Available brands Gudang Garam Clove Cigarettes, Black , Sampoerna A Mild, Djarum 76, Djarum Super. Regards
Pooja Chowdary's picture

k thanx for clarifying my doubt.

pooja

Pooja Chowdary's picture

can you mention some of the medicated lollipops in market?

pooja

Anuya Shrivastava's picture

Dear Pooja, One brand I know about marketed lollipop is Tetracycline lollipops by Bedford Pharmacy. (http://www.bedfordpharmacy.com/_pdf/_patient_info/Tetracaine-lollipop-pa...) Regards
Pooja Chowdary's picture

In which cases tetracyclin lollipops are used?

pooja

Pooja Chowdary's picture

is it possible possible to prepare chewing gums in controlled release formulations?

pooja

Anuya Shrivastava's picture

Dear Pooja, Yes controlled release can be achieved by selecting proper gum & other polymer. Example : Nicotine chewing gum (http://www.dissolutiontech.com/DTresour/200405Articles/DT200405_A02.pdf) Regards
Pooja Chowdary's picture

k then what type of polymer and gum are mostly used?

pooja

Sudha Thamarapalli's picture

hai, Your presentation was very good. You said that these are attractive to pediatrics. But i think that all the 4 types are not suitable for pediatrics because the mediacated chewing gums or lollipops or even bandages have a problem of swallowing which may cause complications. And cigars, i think its not at all practical to give it to children. Regards, SUDHA.T

Regards,

Sudha.T

Anuya Shrivastava's picture

Dear Sudha, Lollipops, chewing gums are designed specifically for pediatrics, so no issues if it is swallowed also, as drugs are non-potent & excipients are biodegradable. About medicated bandages also, it is suitable as same reason given above. About Cigarettes, yes it is not suitable but in Ayurveda, it is prescribed for childrens also. Only thing it has to be done under supervision. Thanks & Reagrds
Pooja Chowdary's picture

oh k thank u for letting me know abt these drugs...

pooja

Anuya Shrivastava's picture

Dear Pooja, Thanks for the appreciation Regards
Pooja Chowdary's picture

Which medicated lillipop is used to treat tooth decay?

pooja

Sandeep Reddy's picture

hi nice presentation because of you i came to now this kind of drug delivary 1)can you give me examples of the marketed products in case of all kinds which you have mentioned in your presentation?
Anuya Shrivastava's picture

Dear Sandeep, I listed examples in answers to questions, kindly refer those & few are enlisted in presentation also. Reagrds
Sirisha Pingali's picture

dear anuya I must congratulate you for presenting such information. All the dosage forms you dealt are brand new for me. Medicated candies are gain to kids and again pain to older people. This is intensified in diabetics. Can these be modified using artificial sweeteners?? By the way are these dosage forms in use?? other than oraljel?? Thank you

Sirisha Pingali

http://www.pharmainfo.net/sirisha

Viswanadha Institute of Pharmaceutical Sciences.

www.vnips.edu.in

Anuya Shrivastava's picture

Dear Sirisha, Thanks for the appreciation. Yes artificial can be used in diabetic patients. Researches are going on such products. I gave answers to others about available brands of each type..kindly refer those. Regards
Harsh bansal's picture

dear anuya i want to know that effect of gastric pH on that kind of products. can we handle it easily??? thank you

harsh bansal

Anuya Shrivastava's picture

Dear Harsh, Drug candidates are selected accordingly, & as such direct contact with gastric pH does not occur. So no detoriated effect of pH is expected. Regards
Pooja Chowdary's picture

can you give some examples for oral syringes?

pooja

Anuya Shrivastava's picture

Refer this site http://www.onnencompany.com/oral_syringes.htm Example NEOSYR01 BAXA5101
Pooja Chowdary's picture

can you explain me about the advantages of oral bandages?

pooja

Anuya Shrivastava's picture

Dear Pooja, it is mentioned in slide No. 13 Advantages: Long-lasting adhesion to the oral mucosa, Resistant to removal by saliva flow in the mouth Protects the affected mucosa from worsening of the lesion due to irritation. Doesn't rely upon chemical reaction to form the adherent, protective film o oral mucosa, as is required with liquid compositions based on Hydroxypropyl Cellulose.
Pooja Chowdary's picture

can you give some examples for medicated lollipops?

pooja

Anuya Shrivastava's picture

Dear Pooja, One brand I know about marketed lollipop is Tetracycline lollipops by Bedford Pharmacy. (http://www.bedfordpharmacy.com/_pdf/_patient_info/Tetracaine-lollipop-pa...) Regards
Harsh bansal's picture

hello anyua i what to know that in which types treatments we can use of oral bandages? i mean in which disease oral bandages is use??

harsh bansal

Anuya Shrivastava's picture

Dear Harsh, Oral bandages are used in oro-pharengeal disorders like mouth ulcer, bacterial infection, inflammation etc. Regards
Pooja Chowdary's picture

Can you give some examples for medicated chewing gums?

pooja

Anuya Shrivastava's picture

Dear Pooja, I am giving a example of patented formula of medicated chewing gum, which contain an acid neutralizing agent, an anti-gas agent, and an acid production inhibitor. (Medicated chewing-gum United States Patent 6537525) Regards
Pooja Chowdary's picture

Are there any other type of unusual dosage forms in market other than which you have mentioned in your ppt?

pooja

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