Pulsatile drug delivery system (PDDS) are gaining importance as these systems deliver the drug at the right site action at right time and in right amount as per the pathophysiological need of the disease which enhances therapeutic activity of the drugs as well as decreases the adverse effects. The principle involved in PDDS is circadian cycle and one can treat the diseases which will exhibit circadian rhythm like asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficient syndrome in children, elevated body temperature, etc. PDDS can be classified into different varieties based on the mechanism responsible for delivery of the drug from the dosage form like time dependent PDDS, pH dependent PDDS, etc. The current review article focuses on the latest technological developments, formulation parameters, and release profiles of these systems.
Key words: PDDS, Circadian rhythm
Profile page link of the author: http://www.pharmainfo.net/arun-kumar-palle
Profile page link of the guide: http://www.pharmainfo.net/ramamohan