Dear Pharmainfo.net friends
I am giving below some information on drug
advice. Each drug advice is divided into two parts, one is information that the
pharmacist must have and the second is information for the patient. In all the
drugs for hypertension, two instructions come commonly. One is about avoiding
grapefruit juice in breakfast when someone is taking antihypertensives. This
direction is incorporated in our advice, based on research reports  , which
report that there is a drug-food interaction between grapefruit juice and
antihypertensives. Grapefruit is not our grape. Grapefruit looks similar to our
orange. The second point is regarding keeping at least one hour gap between
antihypertensives and any other drugs. This is because it is reported  that
among all categories of drugs, it is antihypertensives that show maximum number
of drug interactions.
Information for pharmacist:
- Extended release dosage forms should be swallowed whole without
crushing, breaking or chewing.
- Advice on:
Importance of diet, possible
need for sodium restriction and weight management.
Importance of taking medication
and keeping physician's appointment even if the patient feels fine.
Possible need for lifelong
therapy as atenolol does not cure, but controls hypertension.
Check with physician before
Serious consequences of
Information for patient:
- Take breakfast at 7:30 a.m. and atenolol at 8:00 a.m.
- Take regularly at the same time.
- Do not take grapefruit juice in breakfast, when you are taking
- Do not stop taking without consulting with your physician.
- Do not miss a dose. In case you miss a dose, take it
immediately. If it is within eight hours of the next dose, then take only
the next regular dose.
- Do not combine this medicine with any other. Give at least one
hour gap between this tablet and any other medicine.
- Consult doctor before taking any other medicine like OTC
products for common cold, cough etc along with this medicine.
Pharmaceutical Research, 1999;16:478
Biopharmaceutics and Clinical pharmacokinetics, Milo Gibaldi, Percentage of
hospitalized patients, categorized by drug group, who experienced adverse drug
reactions, (Data from May,F.E., Stewart, R.B., and Cluff,l.E., 4th edition; page 306; Pharmabook syndicate.
3. Advice for the patient: Drug information in
lay language; USP DI; 1995, 15th edition; pg: 406-407.