Associate Scientist, Pharmacology Job

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Date: Jun 10, 2014 Location: San Diego, California, United States Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture. Context Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global biopharmaceutical company engaged primarily in the discovery, development and commercialization of novel therapies for the treatment of cancer and inflammatory diseases through gene and protein regulation. Celgene R&D is at a critical and exciting phase of development. As it expands and integrates its portfolio, there is an opportunity for a dynamic and resourceful individual to contribute to our efforts in Pharmacology Department at our site in San Diego. Pharmacology at Celgene The role of the Pharmacology Department at Celgene is to provide in vivo pharmacology support to discovery teams focused on identifying small molecules or biologics for the treatment of severe unmet medical needs in the areas of oncology, inflammation, autoimmunity and fibrosis. The Pharmacology department also contributes to development teams by providing preclinical data that supports the clinical development plan. The Pharmacology Department is an integrated part of discovery programs, supporting the identification of lead molecules through in vivo model screening and the characterization of the mechanism of action of promising development candidates. The Pharmacology Department is responsible for the development, validation and implementation of acute and chronic animal models of disease, including the identification of pathway biomarkers and clinically relevant endpoints to characterize the efficacy of lead molecules. Members of the department provide leadership for discovery programs from target identification to development candidate nomination. There is a close working relationship with DMPK, Exploratory Toxicology and Translational Development. Summary Reporting to a Principal Scientist, the candidate will have responsibility for the design, planning and execution of in vivo studies focused on identifying drug candidates within the area of fibrosis, inflammation and autoimmunity. Additional responsibilities include sample/endpoint analysis using techniques such as ELISA, Western blot, qPCR, or IHC, data analysis, presentation of data to multidisciplinary discovery teams, participation in the evaluation of new targets and preparation of reports. Responsibilities • Together with senior scientists design, plan and execute in vivo studies focused on identifying drug candidates within the area of fibrosis, inflammation and autoimmunity • Formulation of small molecules and biologics for in vivo studies • Evaluation of pathway biomarkers and endpoints from in vivo studies via techniques such as qPCR, IHC, ELISA, Mesoscale and Western blots • Data capture, analysis and interpretation • Data presentation to multidisciplinary discovery teams • Participate in the evaluation of new targets • Preparation of technical reports • Participate in department meetings • Interface with cross-functional team members Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S. *LI-KM1 Qualifications Technical Skills • Hands-on experience evaluating small molecules and/or biologics in animal models of fibrosis, autoimmune disease or inflammation models • Proficient in animal handling, dosing, sample preparation, experimental design, data analysis and interpretation • Hands-on experience with ELISAs, Mesoscale, Western blots, qPCR or histology preferred. • Experience with siRNA is an advantage • Detail orientated • Excellent written and oral communication skills • Ability to work in a team environment • Computer skills: detailed knowledge of Excel, Word, Powerpoint and Graphpad prism Other Attributes • Experience in problem solving on technical issues • Communicates with cross functional team • Routinely contributes to the achievement of workgroup/team goals • Represents workgroup/team or department on multi-disciplinary or cross functional teams Requirements & Education BS or MS in biology or relevant scientific discipline; minimum six years of industrial or relevant academic experience. Must be a highly flexible, results oriented, independent self-starter who enjoys working in a fast paced environment. Req ID: 14001662 Primary Location: United States-California-San Diego Job: Research and Development Organization: Signal Schedule: Regular Shift: Standard Employee Status: Individual Contributor Job Type: Full-time Job Level: Day Job Travel: No Job Posting: 2014-06-09 00:00:00.0
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Research and Development

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