Alexion Pharmaceuticals, Inc. is a biopharmaceutical company focused on serving patients with severe and ultra-rare disorders through the innovation, development and commercialization of life-transforming therapeutic products. Alexion is the global leader in complement inhibition, and has developed and markets Soliris® (eculizumab) as a treatment for patients with PNH and aHUS, two debilitating, ultra-rare and life-threatening disorders caused by chronic uncontrolled complement activation. Soliris is currently approved in more than 40 countries for the treatment of PNH, and in the United States for the treatment of aHUS. Alexion is evaluating other potential indications for Soliris and is pursuing development of other innovative biotechnology product candidates in early stages of development. This press release and further information about Alexion Pharmaceuticals, Inc. can be found at: www.alexionpharma.com. Position Summary The Associate Director of Preclinical Sciences will be a key member of the Alexion Preclinical department and drive preclinical pharmacology studies that assess the therapeutic potential of new biological entities and their transition into development. In addition, this position will manage the extramural research activities from within the research group and aimed at assessing new therapeutic areas or entities and moving Alexion research pipeline molecules into development. This position will interface cross-functionally with clinicians, scientists from various functions including molecular and cellular biology, clinical-pharmacology, clinical operations, global medical affairs, and business development. The successful candidate will: Principal Responsibilities Direct a highly productive group of preclinical pharmacology scientists in the development of robust disease models and testing of novel therapeutics for ultra-rare diseases Investigate disease pathophysiology and develop scientific evidence for the mechanism of action and the pharmacology of therapeutic candidates Provide scientific and technical support for multidisciplinary project teams, ensure that deliverables align with team milestones and timelines Prepare preclinical protocols, final study or technical reports, write scientific manuscripts, and provide support during the preparation of regulatory submissions Possess excellent oral presentation skills and present study results at both internal meetings and external scientific conferences. Manage both internal and external activities related to external collaborations, including managing supporting staff and scientists. Oversee, manage strategic planning, budget/resource planning related to extramural research programs. Responsible the development of new preclinical pharmacology disease models through external collaborations. Identifies, selects, and manages external CROs engaged in preclinical support. Contribute to business and corporate development and in-licensing evaluations Domestic and international Travel anticipated. Some bench work will be required. Qualifications Minimum 4 years post-doctoral experience and 6+ year experience in either a biotech or pharmaceutical setting. Experience with bone diseases, metabolic or neurological diseases are preferred. Demonstrated track record of effectively allocate effort amongst multiple projects and drive to aggressive timelines Experiences with the preclinical assessment of therapeutic drug candidates. Experience with protein therapeutics and /or rare diseases is preferred. Experience in managing budgets and managing research scientists. Experiences in managing multiple external research collaborations including CROs, academicians, and other external relationships • Good oral and written communication skills with demonstrated successes in writing manuscripts, or supporting regulatory documents Education Ph.D. or equivalent in immunology, pharmacology or other biomedical science with extensive experience in animal pharmacology and supporting assay development.
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Research and Development