Crohn's Disease

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Hi friends, my second topic of this month is Crohn's disease. Crohn's disease is a kind of inflammatory Bowel Syndrome which may affect any part of the gastrointestinal tract (GIT). It causes inflammation of the intestinal tract and might even affect the deeper tissues of the tract. Often occurs in patches surrounded by healthy tissue.[1] It results in Intestinal obstructions, Ulcers (intestinal or rectal),Fistulas, Anal fissures. Patients with this disease also have malnutrition problems, due to impaired absorption in the GIT.[2] CAUSES:: The exact machanism involved in the pathogenesis of this disease is not clear. But it is thought to be, due to exaggerated responses of patient's immune system,and hence is said to be an autoimmune disorder.A person's genetic and environmental factors seem to play a role in the development of Crohn's disease.[1] It may occur in any age, but people of age group 15-35 are at greater risk. The various risk factors include: Cigarette smoking, Family history of Inflammatory bowel disease, Taking high diet rich in sugars and saturated fat and low in fruit and vegetables. [1] SYMPTOMS:[3] 1. Chronic bloody/wtery diarrhoea 2. Abdominal distress 3. Fatigue 4. Anorexia 5. Floating stools 6. Nausea and vomiting 7. Pain while passing stools 8. Constipation 9. Sores 10. Rectal bleeding TREATMENT: [2] The primary goal is to control acute flares of the disease and to maintain remission for as long as possible. This can be achieved with the help of drugs, various nutritional supplements, following balanced diet. Medications commonly used to treat Crohn's disease include: 1. Sulfasalazine (Azulfidine) 2. Mesalamine 3. Corticosteroids (budesonide, prednisone, and prednisolone) 4. Immune system suppressors (include azathioprine, methotrexate, infliximab, adalimumab, certolizumab, natalizumab, and cyclosporine) 5. Antidiarrheal medications (such as diphenoxylate, or psyllium) Patients unresponsive to drugs may have to undergo surgery, depending on the severity of the condition, especially when there are fistulas, hemorrhage or abscesses. Non-pharmacological therapy includes, intake of good amounts of vegetables and fruits preferrably rich in antioxidants, avoiding foods rich in saturated fats and sugar. Along with these vitamin and mineral supplements are also recommended as patients may be deficient of these due to malabsorption problems. "THIS BLOG DOES NOT CONTAIN ANY PLAGIARIZED MATERIAL" References::: 1. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001295/ (ACCESSED ON 27/4/2011) 2. http://www.nlm.nih.gov/medlineplus/crohnsdisease.html (ACCESSED ON 27/4/2011) 3. http://www.umm.edu/altmed/articles/crohns-disease-000043.htm (ACCESSED ON 27/4/2011)
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Author: Gangadhar Hari

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