Tablet Compression Machine: Trends and Demands

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Tablet compression: The process that is opted first if any formulation had to be developed. To meet this demand many changes in the equipment have been made.
This growing demand is due to many factors like: Whether its the case of generics or new formulation, the first trial is carried with tablet compression owing to its lowcost.
The change of pharma market from western to other developing countries like India, and the potency of the API's demands more of protection both in terms of operator and product has led to certain equipment changes.

Advances in Technology:
Many changes have been made to reduce the cost and time and to increase the flexibility, productivity and safety.
Time required to clean the machine during change over of the process has been emphasized.The changes made included
Exchangeable turret - Fette in 1990s.
Openess of teh structure and accessiblity improved in the XL varsions of Korsch.
Centrifugal die filling and clean in place facility by IMA.
In 2002 exchangeable compression module by GEA Courtoy. This ECM technology has combined productivity, flexibility and safety.2
WOL-ECM (wash off-line)- teh latest range of ECM.2
Exchangeable Die disc and die shells- PERFORMA P.2
Stepped cabinet design to allow fast access to the turret, Novel WIP solution capability, - OYSTAR Manesty (Xpress 300, 500 and 700)3

In order to increase the output of tablet presses:
Uniform die filling was necessary to get uniform tablet weight, the prior requirement at high speeds.
Increase in number of punch stations- Die plate segments by Fette.
Exchangeable die disc with die shells by GEA courtoy.
To compensate the decreased dwell time for each tablet, air compensation, larger compression rollers and punches with special head design have been made.
Speed control by AC inverter drive (conventionally variable speed pulley)- UNIK-I FC model with RIMEK brand.4
In case of potent drugs, it would be ideal to have a wash in place tablet compression machine like that of OYSTAR Manesty (Xpress 300, 500 and 700)3 while off line washing is favourable when equipment is smaller, easier to install and operate with low cost.

Formulation Advancements:
Equipment is also altered according to the formulation like those of bilayer tablets.
For example: KORSCH XM 12 5, MODUL P rotary tablet press with Bi-layer ECM 6,Fette high speed bi-layer tablet press-3002.7

Incorporation of sensors like 8
Main compression and Pre-compression sensors: performed by replacing the pins that hold the main and precompression wheels in place.
Ejection sensors: Replacement of ejection cams.
Take off sensors: To measure the forces during tablet from the die table to the collection container.
Torque Sensors: To determine the End point conditions or to measure the amount of work required for mixing a batch of product.
Calibration kits: For calibration of tablet press sensors.

Finally all these advancements of the tablet compression machine should result in tablet of high quality with desired hardness, friability, weight, disintegration and finally dissolution. but, still the quest of the best machine is not quenched suggesting that all this is just the beginning.

"This Blog doesnot contain Plagiarised Material"


1.Primary source: Jan Vogeleer.Tablet Compression: changing trends, more demands. Available from
Secondary sources:

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Author: D Shravani

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