PROTEOMICS CONTINUED!!

Sponsored Links

Hello everyone, Let us continue with our topic PROTEOMICS. With the mild introduction in my previous blog, this time I would like to present the recent advances and applications in proteomics. Proteomics play a vital role in many disciplines today. Integration of Proteomics with Genomics, Metobonomics have further elucidated many unknown results. With these interesting applications, many technological developments have taken place like software and labeling procedures. One of the recent commercialized products available are the Antibody based micro arrays. APPLICATIONS OF PROTEOMICS 1. Disease Biomarkers: Well, with the increasing population, India is being developed under many arenas- These include global recognition to our innovative minds, Technical elevation etc. At the same time, the growth rate of incurable diseases is too bumping. Major stake holder is the Cancer. The benign form of it is curable by means of surgery while the malignant forms eventually lead to death. One of the most common applications of Proteomics is to identify novel biomarkers of cancer. Early detection of the disease helps us in possible treatment. In this regard, Introduction and Refinement of "laser microdissection technology" greatly helped in isolating the diseased cells from the normal cells. 2. Toxicoproteomics: Another application of Proteomics includes the identification of biomarkers for clinical use and of diagnostic assays. Any new drug that is released into the market, before applying for NDA we must assure that the drug is GRAS- Generally Regarded as Safe. That means it should contain a lower toxic profile with superior safety profile. Several investigations have been reported on the application of Proteomics in identifying biomarkers for carcinogenicity and toxicity. 3. System Biology: Experimentation on various biological systems helps us * in identifying key pathways * Better understanding of molecular mechanisms * Loss efficacy * Unexpected toxicities etc 4. Characterization of Serum Proteins: Another major challenge of Proteomics is its application in sequencing Human Serum Protein. Presently the list totally compiled 1175 proteins but the actual number is many a times this figure. Major disturbances occurring in this task is: ? Huge dynamic range of protein concentrations reported ? Domination of serum proteome by other abundantly available proteins ? Appearance of multiple forms of many serum proteins on 2D gels indicating many post translational modifications occurring!!! An alternative approach is the use of Hemodialysis fluid. This fluid contains surplus number of small proteins and polypeptides but hardly contains the major proteins present in blood For eg: Concentration of HSA in hemodialysis fluid is 5,000 times less than normal serum. Ref: http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2006.pto_391.x/full accessed as on August 30, 2011. THE FORTNIGHT TIP Many a times I find people in highly discouraged behaviour or moody. I bet comfort zone is not build with such persons take for grant your friends!! I hope I'm right. In order to grow into a full fledged individual you must have belief, will power and determinate zest to live! I hope everyone is aware of Steve Jobs stepping down as CEO of the tech giant Apple Company. In his mid 40's Jobs was diagnosed with a rare type of Pancreatic Cancer (almost in 2004). Did he loose his will power? No, Not at all! If you observe major products of the company were brought in these 7 years take the iPhone, iPods or iPads. So its all you who design you life architecture!! Good Luck and Keep Going!! Thank you! THIS BLOG IS FREE OF PLAGIARISM
Topic: 

About the Author

Comments

Sandhya Sravya malla's picture

its really a very good topic and i feel it as a worthy opportunity to learn from u thank u sir regards sravya
Dr Girija Sankar's picture

thank you sravya. Infact it is a mutual way. Better teacher is evolved from the best students. Good Luck!!

Dr.G.Girija Sankar, Associate Professor Department of Pharmaceutical Biotechnology, College of Pharmaceutical Science, Andhra University.

Siva Mavuduru's picture

Sir Inspiring tip from you side with an excellent continuation to the last blog. hope this great man steve jobs will live longer.
Dr Girija Sankar's picture

thank you siva. Let us hope for his well being!

Dr.G.Girija Sankar, Associate Professor Department of Pharmaceutical Biotechnology, College of Pharmaceutical Science, Andhra University.

Siva Mavuduru's picture

And in fact I used to feel the two topics which you and sirisha covered are not there in our syllabus but there in jntu syllabus. but because of your blogs i came to know about potenomics and genomics too. thank you so much sir
Dr Girija Sankar's picture

Thank you siva. Syllabus should never be the consideration in gaining knowledge. I'm happy that you got an idea regarding the two topics. Good Luck!!

Dr.G.Girija Sankar, Associate Professor Department of Pharmaceutical Biotechnology, College of Pharmaceutical Science, Andhra University.

You May Also Like..