Hand homogeniser

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DESCRIPTION

Hand homogenizers are the devices which are used to prepare the fine emulsions and suspensions from a coarse emulsion by converting the large globules to small globules.

Hand homogenizers of the classical type are widely used for manual sample preparation.

It is the most probably efficient homogenizer emulsifying apparatus available to the prescription pharmasist.

Used for small scale preparations of emulsions. It is an hand pumped machine.

CONSTRUCTION

It consist of an hopper from which the material is introduced into the homogeniser which consist of a fine orifice.

It consist of an handle which moves up and down movement for the reduction of the particles in the emulsions.

PRINCIPLE

The sliver son homogenizer works on the principle that the large globules in a coarse emulsion are broken into smaller globule by passing them under presure through a narrow orifice.

WORKING

  • It is a simple model suitable for the laboratory work for the homogenisation of small volumes of emulsions and suspensions.
  • It isalso used on the counter of the prescripition pharmasist.
  • Essentially this apparatus consist of a stain less steel vessel mounted on a stand.
  • The bottom of the vessel is narrow and a nozzle with a small aperture is fitted at the end.
  • A small hallow cylinder is fitted to the nozzle inside the vessel.
  • A freely moving pistion is operated in the cylinder with the help of the handle at the top of the vessel.
  • The cylinder has holes above the bottom.
  • The liquid to be homogenized is filled in to the vessel and the piston is operated.
  • The liquid is pressed and passed through the nozzle under the pressure, which causes atomization.
  • Emulsions and suspensions can be homogenized through this apparatus.

Flow of material in hand homogeniser

PHARMACEUTICAL APPLICATIONS

  • Hand Homogenisers are used for rapid sample preparation.
  • The potential use of sterilizing products in situ and modifying the texture of emulsions or biopolymers for food or pharmaceutical applications
  • Suspensions are homogenised in hand homogenizer.
  • For small-scale extemporaneous preparation of emulsions, the inexpensive hand-operated homogenizer is particularly useful.
  • It is probably the most efficient emulsifying apparatus available to the pharmacist and pharmaceutical scientist.
  • Hand homogenizer are used for the preparation of bacteriological food specimens.
  • Hand homogenizer to prepare a more suitable product which are used in U.S. Pharmacist, International Journal of Pharmaceutical Compounding, and Drug Development and Industrial Pharmacy.
  • Hand homogenisers are used to cells of different or origin disrupt tissues, such as tisssue culture cells, biopsies from spleen, liver, lung or muscle. Even plant tissues can be treated.

ADVANTAGES

  • For small-scale extemporaneous preparation of emulsions, the inexpensive hand-operated homogenizer is particularly used.
  • This type of equipment are lack of contamination in the final product and ease of production scale up.
  • Allowed normal assembly technology.
  • Another advantage of the homogenizer is to enlarge mechanical assembly tolerance.
  • Hand homogenizer pass the sample through 10-20 times until a fine homogenate is obtained.

DISADVANTAGES

  • The disadvantage is that the homogenizers produce aerosols, which can be harmful especially when handling.
  • Large masses of tissue, even when homogenized, may result in decreased yields.
  • It produces very small gap size is reduced throughput.
  • Drawback of the homogenization approach is the point connection between two elements.

REFERENCES

  1. Dr. P. V. Kasture, Pharmaceutics - I, 2008.
  2. Mehta RM, Pharmaceutics-I: Mixing and Homogenisation (1996), Page no:116.

About the Author

Saraswathi.B's picture
Author: Saraswathi.B

Assistant Professor in St. johns college of pharmacy

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