which one of the folllowing statements is FALSE about Interferons?

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A) Interferons are cellular glycoproteins produced by virus infected cell
(B) Interferons have no effects on extracellular virus
(C) Interferons are virus specific agents that can interfere either with DNA or RNA
(D) They are produced as potent broad spectrum antiviral agents


Saraswathi.B's picture


Interferons have no effects on extracellular virus

Interferons (IFNs) are the proteins which are released by host cells due to the presence of the pathogens such as viruses, bacteria, parasites, or tumor cells. The virus-infected cell will release interferons and also shows action on other extracellular viruses and produces broad spectrum anti viral action.

Interferons belonging to the proteins class known as cytokines, this molecules shows protective defenses of the immune system and help in destruction of pathogens. Interferons interfers with the viral replication by protecting cells from the virus conditions.

Other functions:

a. Activate immune cells such as natural killer cells and macrophages.

b. They increase host defenses by increasing the expression of major histo compatibility complex (MHC) antigens.

Based on the genes and protein in animals and the presence of receptors in humans the interferons are divided into 3 classes

a) Type I IF : All type I interferons binds to a specific cell surface receptor complex known as the IFN-a/v receptor ( IFNAR1, IFNAR2 CHAINS). The inferferons present in the human are IFN-a, IFN-v, IFN-e, IFN-K and IFN-o.

b) Type II IFN: It binds to IFNGR ( IFNGR1 and IFNGR2 chains). In humans the interferon present is IFN-g.

c) Type III IFN: Signal through a receptor complex consisting of IL10R2 which is also called as CRF2-4 and IFNLR1 which is also called as CRF2-12.

All three are important which fights against viral infections and for the regulation of the immune system.

A virus-infected cell releases viral particles that can infect nearby cells.

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