Sitagliptin is a

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  1. PPAr - gama activator
  2. hypoglycemic agent
  3. glucagone like protein analogue
  4. dipeptidyl peptidase inhibitors


Saraswathi.B's picture


Dipeptidyl peptidase inhibitors


Sitagliptin is an oral anti hyperglycemic or anti diabetic drug and the inhibitor of dipeptidyl peptidase -4(DPP- 4). It inhibits the enzyme called as dipeptidyl peptidase 4 (DPP-4). This drug inhibits the enzyme. It break down incretin GLP-1 and gastro intestinal hormones and are able to increase the secretion of insulin and suppress the release of glucagon by the pancreas.

Side effects of the drug are stuffed or runny nose, sore throat, headache and diarrhea, ongoing pain, nausea, vomiting, loss of appetite.

PPAr are called as peroxisome proliferators activated receptor gamma which is also called as glitazone receptors or nuclear receptor ub family 1, group C, member 3 which is a type 2 of nuclear receptor. It regulates fatty acids storage and glucose metabolism.

Glucagon like peptide - 1 or protein is derived from the transcription product of the proglucagon gene which is also called as incretin.

GLP-1 restores the glucose senstivity of pancreatic beta cells. It also inhibits pancreatic beta cell apoptosis and stimulate the proliferation and differentiation of insulin-secreting v-cells. GLP-1 also inhibits gastric secretion and motility.

Hypoglycemic agent used in the treatment of type 2 diabetes which is a disorder involving resistance to secreted insulin.

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