18. Which of the following statements is false for artemisinin ?

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  1. It is a sesquiterpene lactose endoperoxide
  2. It is a drug of choice in prophylaxis of malaria
  3. It does not cure relapsing malaria
  4. It is useful in treatment of cerebral falciparum malaria

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Saraswathi.B's picture

Answer: 

It is a drug of choice in prophylaxis of malaria

Artemisinin

Artemisinin is also known as the Qinghaosu which is derived drugs possesses on set of rapid action and acts against Plasmodium falciparum malaria. it is obtained from the plant Artemisia annua. it consist of peroxide bridge which is an sesquiterpene lactone responsible for the mechanism of drug action. It is a drug of choice in prophylaxis of malaria in both well tolerated and effective patients. it is also used in the treatment of cancer cell. and incerasinly used in Plasmodium vivax malaria.

it shows anti malarial action by killing the parasites.

mechanism

anti malarial action can obtained by the radical formation which mainly depends on the endo peroxide bridge

malaria infects a red blood cell ----- insect consumes hemoglobin with in its digestive vacuole ------- possesses oxidative stress -------- iron of heme reduces the peroxide bond directly in the artemisinin ------------ generates high-valent iron oxo species -------- produce reactive oxygen radicals ---------- damages the parasite ------ death.

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