why diuretic are used in hypertensive therapy

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P.V.ABHIGNA's picture

Diuretics: Use of diuretics causes a significant increase in the amount of water and electrolytes excreted in urine, which leads to a reduction in the volume of extracellular fluid and plasma. This in turn leads to a reduction of cardiac output which is the main parameter responsible for a drop in arterial blood pressure and venous blood return. Cardiac out put is gradually restored but the hypotensive effect remains possibly because of reduced peripheral resistance of vessels. REF:MEDICINAL CHEMISTRY BY WILLIAM FOYE page-731


Shruti Priya's picture

Diuretics are preferred for hypertension as they allow a simple dosage regimen i.e.once a day and causes no fluid retention and tolerance.Also, they are relatively free from CNS side effects.they can be used in elderly people without causing risk. Reference:Essentials of Medical Pharmacology, KD Tripathi Page no.541

Shruti Priya

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