Where is histamine stored in the body?

Sponsored Links


Eswar GsnkRao's picture


Histamine is stored majorily in specialized cells called MAST CELLS.


ESWAR :-) 

Dr Pranav Kumar Prabhakar's picture


Most histamine in the body is generated in granules in mast cells and in white blood cells called basophils andeosinophils. Mast cells are especially numerous at sites of potential injury -- the nose, mouth, and feet, internal body surfaces, and blood vessels. Non-mast cell histamine is found in several tissues, including the brain, where it functions as a neurotransmitter. Another important site of histamine storage and release is the enterochromaffin-like (ECL) cell of the stomach.

The most important pathophysiologic mechanism of mast cell and basophil histamine release is immunologic. These cells, if sensitized byIgE antibodies attached to their membranesdegranulate when exposed to the appropriate antigen. Certain amines and alkaloids, including such drugs as morphine, and curare alkaloids, can displace histamine in granules and cause its release. Antibiotics likepolymyxin are also found to stimulate histamine release.

Histamine release occurs when allergens bind to mast-cell-bound IgE antibodies. Reduction of IgE overproduction may lower the likelihood of allergens finding sufficient free IgE to trigger a mast-cell-release of histamine.

You May Also Like..