What is the location of Vasopressin-1a receptor and vasopressin-1b receptor?

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K Rajakrishna's picture

The V1a receptor is the most widespread subtype of vasopressin receptor; it is found in vascular smooth muscle, the adrenal gland, myometrium, the bladder, adipocytes, hepatocytes, platelets, renal medullary interstitial cells, vasa recta in the renal microcirculation, epithelial cells in the renal cortical collecting-duct, spleen, testis, and many CNS structures. V1b receptors have a more limited distribution and are found in the anterior pituitary, several brain regions, the pancreas, and the adrenal medulla. reference: Manual of Pharmacology and Therapeutics - Godman and Gilman, pg.no- 501
Seema Meena's picture

Summary of vasopressin receptors AVPR1A phosphatidylinositol/calcium liver, kidney, peripheral vasculature, brain vasoconstriction, gluconeogenesis, platelet aggregation, and release of factor VIII and von Willebrand factor; social recognition[2], circadian tau[3] AVPR1B phosphatidylinositol/calcium pituitary gland, brain adrenocorticotropic hormone secretion in response to stress[4]; social interpretation to olfactory cues[5] AVPR2 adenylate cyclase/cAMP apical membrane of the cells lining the collecting ducts of the kidneys (especially the cortical and outer medullary collecting ducts) insertion of aquaporin-2 (AQP2) channels (water channels). ref http://en.citizendium.org/wiki/Vasopressin_receptor


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