What is meant by partition coefficient?

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Narmadha's picture

Partition coefficient(PC)is an important physicochemical property that is used to predict the diffusion of drugs.A rough guide is: the higher the PC, the better is its lipid solubility. Partition coefficient(PC)=conc.of drug in oil phase/conc.of drug in water phase. Refference-TEXTBOOK OF PHYSICAL PHARMACEUTICS by C.V.S.Subrahmanyam Page no.122

With regards, Narmadha  

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