what is the difference between Pharmacosomes and Neosomes??

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Satheesh Babu's picture

Answer: 
Pharmacosomes are amphiphilic lipid vesicular systems that have shown their potential in improving the bioavailability of poorly water soluble and poorly lipophilic drugs. Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. REFERENCES: Dr. Rakesh P. Patel, pharmainfo.net, Niosome: An Unique Drug Delivery System Semalty A, Semalty M, Singh D, Rawat MS,Development and physicochemical evaluation of pharmacosomes of diclofenac. Acta Pharm. (2009) Sep;59(3):335-44.
Ayman Waddad's picture

Answer: 

Niosomes a non-ionic surfactant based vesicles formed by the self assembly of non-ionic amiphiles in aqueous medium resulting in closed aqueous bilayer structure. To have spontaneous formtion of this bilayer structure; physical agitation (Sort of energy) should be applied. Pharmacosomes are colloidal dispersion of a drug covalently bound to a lipid result in ultrafine vesicular, micellar or hexagonal aggregates according to the nature of the drug-lipid complex.

References:

1. Uchegbu, I. F. and S. P. Vyas (1998). "Non-ionic surfactant based vesicles (niosomes) in drug delivery." International Journal of Pharmaceutics 172: 33-70.

2. D, K., N. S. J, et al. (2010). "PHARMACOSOMES: AN EMERGING VESICULAR SYSTEM." International Journal of Pharmaceutical Sciences Review and Research 5(3): 168-171.

Ayman Waddad

Ph.D Student

China Pharmaceutical University

Nanjing

China

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