when to prefer off column derivatization in gas chromatography

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N Vijaya Lakshmi's picture

Answer: 

Generaly column derivatization is preferred to increase the detectability of various classes of compounds in case of HPLC. But in GC these is a presence ofselective detectors for all type of compounds where there is a no need of column derivatization.

Off column derivatization helps to increase column life by protecting it from deleterious alkylating agents.

Regards

N. Vijaya Lakshmi

Asst. Prof.

Hindu College of Pharmacy.

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