Which is the requisite nature of particles in pulmonary drug delivery? In case of size, shape and texture?

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Satheesh Babu's picture

ideal size for therapeutic aerosols to be between 0.5-7.0 m. Particles larger than 7.0 m are not believed to be able to penetrate beyond the trachea, whereas particles smaller than 0.5 m are most probably exhaled. Anisometric particles, which have an elongated or flattened shape, tend to build up open packings of higher porosity. In aerosol , the use of elongated particles has attracted much interest. Long objects, such as fibres and needle-like crystals, have aerodynamic diameters almost independent of their length and the diameter is approximately equal to the shortest dimension of the particle in question. Thus, elongated particles may exhibit a much smaller aerodynamic diameter than spherical particles of similar mass or volume. ref: Particulate Interactions in Dry Powder Formulations for Inhalation edited by, Xian Ming Zeng Gary P. Martin Christopher Marriott Department of Pharmacy, King's College London

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