What are the drug candidates that need colon targeting?

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Shikha Chauhan's picture

Inflamatory Bowel diseases such as Ulcerative Colitis and Crohn's diseases require selective local delivery of drugs to the colon. Reference: Advances in Controlled Drug Delivery , By N.K. Jain, page no 97

Thanks and Regards, Shikha Chauhan http://www.pharmainfo.net/shikhachauhan/biography Lecturer (Pharmaceutics) Amity Institute of Pharmacy Amity University Noida Email: schauhan@amity.edu

Satheesh Babu's picture

Sulfasalazine, ipsalazide and olsalazine have been developed as colon-specific delivery systems for the treatment of inflammatory bowel disease (IBD). irritable bowel syndrome, and colonic cancer. Aminosalicylates, corticosteroids, immunosuppressive agents, cationized antioxidant enzymes, protein-peptide drugs such as insulin, calcitonin, and met-enkaphalin and even for other nonpeptide drugs such as cardiovascular and antiasthmatic agents. to achieve oral colon-targeted delivery. REF: Drugs Today 1999, 35(7): 537 Crit Rev Ther Drug Carrier Syst (2007) 24: 147-202.

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