surface area always directly praportional to dissolution rate. True or false?

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S.M. Habibur rahman's picture

Answer: 
The mentioned statement is true
Satheesh Babu's picture

Answer: 
true. because contact area of the particles is more in the dissolution medium. so particle surface area and dissolution rate is directly proportional.
Dr. T.E.G.K. Murthy's picture

Answer: 
The statement is not true due to the possible presence of electro static interactions and the predominant cohesive forces in case of micronisation and the resulting high surface area may lead to aggregation of solid particles and the effective surface area available for dissolution is decreased.Effective surface area is more important than actual surface area.

Dr.T.E.G.K.Murthy
http://www.pharmainfo.net/tegkmurthy/biography
Principal
Bapatla College of Pharmacy, Bapatla

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