What are bence jones proteins?

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Santosh kumar. JH's picture

Bence Jones proteins are characteristic small dimers of immunoglobulin light chains, produced by plasma cells and are excreted by the kidney in patients with multiple myeloma whose quantity is used to diagnose the disease. Ref: http://www.encyclo.co.uk/define/bence%20jones%20protein
P.V.ABHIGNA's picture

Henry Bence Jones first described them.They are light chains of immunoglobulins that are synthesized in excess.They have a molecular weight of 20000 to 40000(for dimer).In about 20% of patients of multiple myeloma these are excreted in urine which often damage renal tubules. REF:BIOCHEMISTRY-Dr.U.Satyanarayana and Dr.U.Chakrapani.3rd EDITION .Page-189


Uma Pratyusha's picture

Hi Pratibha, Bence jones proteins are the light chains of antibodies synthesized in excess. ref; BIOCHEMISTRY-Dr.U.Satyanarayana.3rd EDITION .Page-189


Uma Prathyusha

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