How to diagonize sickle-cell anaemia?

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P.V.ABHIGNA's picture

Answer: 
DIAGNOSIS of sickle cell anemia: 1)Sickling test:Microscopic examination of blood smear after addition of sodium dithionite shows sickled erythrocytes. 2)Electrophoresis:When sickle cell Hb is subjected to electrophoresis it moves slowly towards anode which is due to less negative charge caused by the absence of glutamate residues that carry negative charge. REF:BIOCHEMISTRY-Dr.U.Satyanarayana and Dr.U.Chakrapani.3rd EDITION .Page-206

ABHIGNA.P.V.

Uma Pratyusha's picture

Answer: 
Hi Pratibha, Sickle cell anaemia can be diagnosed by sickling's test and electrophoresis. ref: Biochemistry text book by U.Satyanarayana, 3rd edition, pg-206

Regards

Uma Prathyusha

Shruti Priya's picture

Answer: 
Dear Uma and Abhigna, Prenatal diagnosis (before birth) of sickle cell anemia is possible using amniocentesis or chorionic villus sampling. The sample obtained is then tested for DNA analysis of the fetal cells. http://www.medicinenet.com/sickle_cell/page3.htm accessed on 20.1.2011

Shruti Priya

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