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Sorry earlier i forgot to write reference. MECHANISM OF ACTION OF CORTICOSTEROIDS Corticosteroids are the steroidal hormones secreted by the adrenal cortex . Corticods are 21 carbon compound having a cyclopentanoperhydro-phenanthrene nucleus. Steroidogenesis take place under the influence of ACTH which makes more cholesterol available for conversion to pregnenolone and induces steroidogenic enzymes. It mainly include the mineralocorticoids (aldosterone) and glucocorticoids (hydrocortisone, pregninolone) and some weak androgens like dehydroepiandrosterone and androstenedione. Corticosteroids penetrate the cell and then they bind to high affinity cytoplasmic receptors. As a result a structural change occurs in the steroidal receptor complex and it then get migratded to nucleus. In the nucleus it binds to glucocortecoid response element (GRE) on the chromatin. Then it causes the transcription of specific m RNA and regulate the synthesis of various proteins. This whole process take place with in 30 min. The action made by the glucocorticoids are exerted more rapidly . In a feed back inhibition system they inhibit the secretion of the Corticotropin Releasing Harmone (CRH) from hypothalamus and the ACTH ( Adrenocortico tropic harmone) from the pituitary gland to diminish there secretion. Aldosterone are secreted from the Glomerulosa , hydrocortisone from the Fasciculata and Dehydroapiendrosterone from the reticularis of adrenal cortex. They regulate the body fluid-electrolyte balace, cardiovascular and energy substrate homeostasis and functional status of the skeletal muscles and nervous system. REFERENCE : Essentials of Medical Pharmacology,Jaypee publications, K.D. Tripathi , page no.275-287 THIS BLOG DOES NOT CONTAIN ANY PLAGIARIZED INFORMATION

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Author: Amol Dhiaman

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