Therapeutic Applications of Aerosols

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Therapeutic Applications of Aerosols

10) Therapeutic Applications of Aerosols 1,5,11

  • Pharmacist has to educate the patient about aerosol dosage forms, particularly for oral or nasal administration, because these are effective, only when properly used.
  • Pharmacist should give the written instructions to patient in the product package.
  • Pharmacist must explain for proper use of aerosols.
  • Patient should ask to pharmacist for any other queries on usage of aerosols.

Topical Aerosols

Convenient aerosol packages for use on the skin include the anti-infective agents like povidone iodine, tolnaftate, thimerosal, adrenocortical steroids like betamethasone dipropionate, valerate, dexamethasone, triamcinolone acetonide and the local anesthetic dibucaine hydrochloride.

The use of topical aerosols applying the drug in a convenient manner on affected area. The formulation can be applied to the desired surface area without the use of the fingertips like other types of topical preparations.

Disadvantages for topical aerosols are, the difficulty in applying the medication to a small area and the greater expense associated with the aerosol package.

Vaginal and Rectal Aerosols

SVaginal and Rectal Aerosolsome commercially available aerosol foams containing estrogenic substances and contraceptive agents. The foams are used intravaginally similarly as for creams. The product package contains an inserter which is filled with foam and the contents are placed in the vagina through activation of the plunger. Generally the foams are o/w type of emulsions appears as light creams. Foams are water miscible and nongreasy.

Some commercial rectal foams use inserters. Such product is ProctoFoam (Schwartz) contains pramoxine hydrochloride to relieve inflammatory anorectal disorders.

Oral Aerosols

Aerosols are used to deliver the drugs to the oral cavity generally administer the product sublingually. For example sublingual nitroglycerin aerosol formulation is sprayed under the tongue and it delivers 0.4 mg of nitroglycerin per actuation depends on the valve used.

Inhalation Aerosols/ Nasal Aerosols

Inhalation Aerosols or Nasal AerosolsInhalation aerosols deliver the drug directly to the nasal mucosa of nose. The most of nasal aerosols contain steroids, which are used to treat sneezing, nasal congestion and running nose along with hay fever, rhinitis and allergies. Examples for Inhalation or Nasal aerosol products contain steroids beclomethasone dipropionate, dexamethasone sodium phosphate, triamcinolone acetonide and budesonide.

Examples of Inhalation Aerosols 5


Some Commercial Products

Category and Comments

Albuterol Inhalation Aerosol

Proventil Inhalation

Aerosol (Schering)

Ventolin Inhalation Aerosol


Beta-adrenergic agonist for

prevention and relief of

bronchospasm in patients with

reversible obstructive airway

disease and for relief of exercise induced


Beconase Nasal Inhaler

(Alien & Hanburys)

Vancenase Pockethaler Nasal Inhaler


Adenocortical steroid, aerosol for intranasal relief of symptoms of seasonal or perennial rhinitis in those cases poorly responsive to conventional treatment.

Ipratropium bromide Aerosol

Atrovent Inhalation Aerosol

(Boehringer Ingelheim)

Anticholinergic and

Bronchodilator for Bronchospasm

Cromolyn. sodium Inhalation Aerosol

Intal Inhaler

(Rhone-Poulene Rorer)

An antiasthamatic, Antiallergic and mast cell stabilizer, metered-dose aerosol for oral admistration for prevention of exercise - induced bronchospasm, and for prevention of acute branchospasm induced by environmental pollutants and allergins.

Isoetharine mesylate Inhalation aerosol

(Sonafi) Bronkometer

Sympathomimetic for the temporary relief of bronchial asthma and other conditions of branchospasm.

Metaprolal Sulphate Inhalation Aerosol

Alupent Inhalation Aerosol

(Boehringer Ingelheim)

Sympathomimetic for the temporary relief of bronchospasm in patients with reversible obstructive airway disease.

Nedocromil Sodium Inhalation Aerosol

Tilade Inhaler

(Rhone - Poulenc Rorer)

Maintenance therapy of patients with mild to moderate bronchial asthma


Some Commercial Products

Category and Comments

Salmeterol Xinafoate Inhalation Aerosols

Serevent Inhalation Aerosol

(Glaxo Wellcome)

Beta-adrenergic agonist for the ongterm maintenance treatment of asthma and bronchospasm in patients with

reversible obstructive airway


Terbutaline Sulfate (Inhalation Aerosol)



Beta-adrenergic agonist for

prevention and relief of


Triamcinolone Acetamide Oral Inhaler

Azmacort (Rhone - Poulenc Rorer)

Indicated in patients who require chronic treatment with corticosteroids for the control of symptoms of bronchial asthma.

Triamcinolone Acetamide topical Aerosol

Kenalog Spray (Westwood - Squibb)

Anti-Inflammatory applied topically to the affected area.

About the Author

Naseeb Basha Shaik's picture

Working as Assistant Professor, Pharmaceutics Department at G.Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad.


Eswar GsnkRao's picture

Dear Basha,

The book chapter on Aerosols is very impressive and I wish you would come up with many more such contributions for the benefit of Pharma fraternity.

Keep it up and All the Best.


ESWAR :-) 

Naseeb Basha Shaik's picture

Thank you

Naseeb Basha Shaik

Assistant Professor

G. Pula Reddy College of Pharmacy, Hyderabad-28.

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